Identifying downstream effectors of a venous specific adhesion pathway

Arteries and veins are lined by endothelial cells with different adhesive properties to facilitate vessel-specific barrier function. For example, the arterial system is exposed to high pressure from blood flow, compared to the low-pressure venous system. Endothelial cells in arteries therefore form strong cell-cell contacts, whilst venous endothelial cells are more loosely connected, which facilitates passage of large molecules and immune cells. What controls these adhesion differences is poorly understood. We have recently identified a novel venous-specific pathway that controls cell-cell adhesion specifically in veins. This project will functionally analyse downstream effectors of this pathway by high end live imaging of the blood vasculature in zebrafish, complemented by further mechanistic studies in human endothelial cells (2D monolayers & bioengineered 3D human micro-vessels).

Associate Professor Lagendijk will train and mentor the HDR student within the outstanding academic environment of the IMB/UQ. The Trainee will receive multi-disciplinary training in developmental genetics, bioengineering, cell biology and high-resolution live imaging. This will provide a strong basis for careers in academic research, bioengineering and tissue engineering.

Facilities: IMB Microscopy facility for high-end live imaging, UQBR zebrafish facility, PCS2 cell culture facility, QLD node ANFF for biofabrication of 3D micro-vessel devices.

This is an Fellowship support scheme scholarship project that aligns with a recently awarded Australian Government grant.

The scholarship includes:

• living stipend of $36,400 per annum tax free (2025 rate), indexed annually
• your tuition fees covered
• single overseas student health cover (OSHC).

Learn more about the Fellowship support scheme scholarship.

Your application will be assessed on a competitive basis.

We take into account your:

• previous academic record
• publication record
• honours and awards
• employment history

A working knowledge of microscopy would be of benefit to someone working on this project. Experience with animal models is highly desirable.

You’ll demonstrate academic achievement in the fields of cell biology, developmental biology, and and the potential for scholastic success.

A background or knowledge of cardiovascular research is highly desirable.

This project requires candidates to commence no later than Research Quarter 1, 2027. You can start in an earlier research quarter.

You must submit an expression of interest (EOI) by the closing date for the research quarter (RQ) you want to start in:

Before you apply

1. Check your eligibility for the Doctor of Philosophy (PhD).
2. Prepare your documentation.
3. If you have any questions about whether the project is suitable for your research interests, contact Associate Professor Anne Lagendijk (a.lagendijk@imb.uq.edu.au).

When you apply

To apply, submit an expression of interest (EOI) for the program. You don't need to apply separately for the project or scholarship. How to submit an EOI

In your EOI, complete the 'Scholarship/Sponsorship' section with the following details:

1. Are you applying for an advertised project: 'Yes'
2. Project: 'Fellowship project scholarship'
3. Scholarship Code Listed in the Advertisement: LAGENDIJK-270825
4. Link to Scholarship Advertisement: https://study.uq.edu.au/study-options/phd-mphil-professional-doctorate/projects/identifying-downstream-effectors-venous-specific-adhesion-pathway

Submit an EOI