Swift transitions - Decoding the chromatin dynamics that redirect cell behaviour during vessel growth

Cells in developing embryos must coordinate gene expression that instructs outputs such as proliferation, migration and differentiation. Each output has a defined signature, yet cells swiftly switch between proliferation and migration while maintaining differentiation. 

Our recent work shows that chromatin organisation drives differentiation in lymphatic endothelial cells – however, its role in dynamic outputs and the transcriptional programme of proliferating or migrating cells is unknown.

In this project, you'll define chromatin dynamics in proliferating and migrating lymphatic endothelial cells, and uncover the mechanisms controlling these outputs. 

Using live imaging of zebrafish embryos, you'll investigate how chromatin organisation and signalling pathways shape these processes. 

By combining high-resolution microscopy with genomic and epigenetic approaches, you will reveal 3D chromatin organisation and the transcriptional changes enabling swift state switching.

Work in Dr. Kaska Koltowska's laboratory (School of Biomedical Sciences) with access to the microscopy facility and UQ Biological Resources zebrafish facility.

This project is supported by the Research project scholarship.

Learn more about the Research project scholarship.

Your application will be assessed on a competitive basis.

We take into account your:

• previous academic record
• publication record
• honours and awards
• employment history.

You must submit an expression of interest (EOI) by 8 September, 2026 8 September, 2026.

Before you apply

1. Check your eligibility for the Doctor of Philosophy (PhD).
2. Prepare your documentation.
3. If you have any questions about whether the project is suitable for your research interests, contact Dr Kaska Koltowska (k.koltowska@uq.edu.au).

When you apply

To apply, submit an expression of interest (EOI) for the program. You don't need to apply separately for the project or scholarship. How to submit an EOI

In your EOI, complete the ‘Scholarship/Sponsorship’ section with the following details:

1. Are you applying for an advertised project: 'Yes'
2. Project: 'Research project scholarship'
3. Scholarship Code Listed in the Advertisement: TRANSITIONS-KOLTOWSKA
4. Link to Scholarship Advertisement: https://study.uq.edu.au/study-options/phd-mphil-professional-doctorate/projects/swift-transitions-decoding-chromatin-dynamics-redirect-cell-behaviour-during-vessel-growth

Submit an EOI